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美国Stemedica公司申请专利26项,其中 7项已获批,主要集中在干细胞生产工艺、干细胞和细胞因子用途方面。公司拥有干细胞规模化生产保密技术,是实现干细胞制药的关键技术。

自2012年以来,美国Stemedica公司及其合作伙伴共发表高水平研究论文15篇:

1、Ivan Cheng, Robert E.Mayle, etc. Functional Assessment of The Acute Local and Distal Transplantation of Human Neural Stem Cells after Spinal Cord Injury. Spine J 2012; 12(11):1040-4 

2、Alex Kharazi; Michael L Levy, etc. Chicken Embryonic Brain: An in vivo Model for Verifying Neural Stem Cell Potency. J. Neurosurg. 2013; 119(2):512-9

3、D Y Park;R E Mayle;R L Smith,etc. Combined Transplantation of Human Neuronal and Mesenchymal Stem Cells following Spinal Cord Injury. Global Spine J 2013; 3(1):1-6

4、Grigory Vertelov; Ludmila Kharazi, etc. High Targeted Migration of Human Mesenchymal Stem Cells Grown in Hypoxia is Associated with Enhanced Activation of RhoA. Stem Cell Res Ther 2013; 4(1):5

5、Anita A Kelkar; Javed Butler, etc. Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy. J. Am. Coll. Cardiol. 2015; 66(18):2038-2047 

6、Ivan Cheng; Michael Githens, etc. Local Versus Distal Transplantation of Human Neural Stem Cells following Chronic Spinal Cord Injury. Spine J 2016; 16(6):764-9

7、Stephen J Greene; Stephen E Epstein, etc. Rationale and Design of a Randomized Controlled Trial of Allogeneic Mesenchymal Stem Cells in Patients with Nonischemic Cardiomyopathy. J Cardiovasc Med (Hagerstown) 2017; 18(4):283-290

8、Mihai Gheorghiade, Christopher J. Larson, etc. Developing New Treatments for Heart Failure Focus on the Heart. Circ Heart Fail. 2016 May;9(5).

9、Dror Luger; Michael J Lipinski, etc. Intravenously-delivered Mesenchymal Stem Cells: Systemic Anti-inflammatory Effects Improve Left Ventricular Dysfunction in Acute Myocardial Infarction and Ischemic Cardiomyopathy. Circ. Res. 2017; 120(10):1598-1613

10、Grigory Vertelov; Edgar Gutierrez, etc. Rigidity of Silicone Substrates controls cell Spreading and Stem Cell Differentiation. Sci. Rep. 2016; 6:33411

11、Taoufiq Harach; Fabien Jammes, etc. Administrations of Human Adult Ischemia-Tolerant Mesenchymal Stem Cells and Factors Reduce Amyloid-Beta Pathology in a Mouse Model of Alzheimer’s Disease. Neurobiol. Aging 2017; 51:83-96

12、Javed Butler, Stephen E. Epstein, etc. Intravenous Allogeneic Mesenchymal Stem Cells for Non-Ischemic Cardiomopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial. Circulation Research.2016.

13、T Harach; N Marungruang, etc. Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep 2017; 7:41802

14、Ivan Cheng etc. Does timing of transplantation of neural stem cells following spinal cord injury affect outcomes in an animal model J Spine Surg 2017;3(4):567-571

15、Michael L. Levy, John R. Crawford, Nabil Dib, Michael L, et al. Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke. Stroke. 2019 Oct;50(10):2835-2841.

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